EPITALON

Chemical Makeup:

• Molecular Formula: C₁₄H₂₂N₄O₉
• Molecular Weight: 390.4 g/mol
• Synonyms: Epithalon, AEDG Peptide, Synthetic Epithalamin, AGAG.

Sequence:

• L-Alanyl-L-alpha-glutamyl-L-alpha-aspartyl-glycine

[EPITALON] and Telomere Elongation

In cytogenetic studies involving human somatic cells, the introduction of [EPITALON] was observed to induce telomerase activity. Research conducted on human fetal fibroblast cultures demonstrated that the peptide promoted the elongation of telomeres, effectively increasing the number of cell doublings (passages) by approximately 42.5% compared to controls. These findings suggest a potential role in delaying cellular senescence and extending the functional lifespan of cell lines in vitro.

[EPITALON] and Circadian Regulation

The influence of [EPITALON] on the pineal gland has been documented in primate models. In studies involving aged Macaca mulatta (rhesus monkeys), administration of the peptide was correlated with a restoration of nocturnal melatonin secretion levels comparable to those of young animals. Furthermore, cortisol circadian patterns, which are often disrupted in aging models, were observed to normalize following the research protocol. This suggests an interaction with the hypothalamic-pituitary-adrenal axis to re-establish homeostatic rhythmicity.

[EPITALON] and Retinal Health

Research in ophthalmologic models, specifically utilizing Campbell rats with hereditary retinitis pigmentosa, indicated that [EPITALON] may preserve retinal structural integrity. Histological analysis showed that the peptide delayed the degenerative loss of photoreceptor cells. In additional models of diabetic retinopathy, [EPITALON] was noted to reduce intracellular reactive oxygen species (ROS) and inhibit fibrosis, suggesting a mechanism of protection against oxidative stress within ocular tissues.

[EPITALON] and Tumorigenesis

Long-term bioassays in murine models have investigated the peptide's safety profile regarding spontaneous tumor development. Contrary to concerns that telomerase activation might promote unchecked cell growth, studies in female mice prone to mammary tumors (C3H/Sn strain) indicated a statistically significant decrease in tumor incidence and metastasis in the [EPITALON]-treated groups. It is hypothesized that the peptide’s regulatory effect on the neuroendocrine system and immune function contributes to an anti-tumorigenic environment.

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Adverse Events in Research: 

In preclinical animal studies (rodents and primates), [EPITALON] has demonstrated a high safety profile with no reported acute toxicity at standard research dosages. Side effects noted in limited observations generally relate to administration procedures, such as mild irritation at the injection site. No withdrawal symptoms have been documented in the literature following the cessation of administration in animal models.

Storage Instructions:

• Lyophilized: Store at -20°C for up to 36 months.
• Reconstituted: Store at 4°C and use within 14-21 days. Avoid repeated freeze-thaw cycles.

WARNING:

RESEARCH USE ONLY! This product is intended for laboratory research and development purposes only. It is not intended for human consumption, diagnostic use, or therapeutic application. The physiological effects described are based on published animal and in vitro studies. Handling should be performed by qualified professionals wearing appropriate personal protective equipment (PPE).