AOD-9604

Chemical Makeup:

• Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂
• Molecular Weight: 1815.1 g/mol
• Synonyms: Tyr-hGH Frag 177-191, Lipotropin, Anti-Obesity Drug 9604

[AOD-9604] and Adipose Tissue Metabolism

In murine models of obesity, [AOD-9604] has been observed to influence lipid metabolism significantly. Research conducted by Heffernan et al. (2001) indicated that chronic administration of the peptide in ob/ob mice resulted in a reduction of body weight gain and an increase in lipolytic sensitivity. The peptide appears to stimulate the breakdown of triglycerides in adipose tissue and increase fat oxidation. Notably, these effects were achieved without the induction of insulin resistance or glucose intolerance, which are common side effects associated with full-length hGH administration in similar models.

[AOD-9604] and Cartilage Regeneration

Beyond metabolic research, [AOD-9604] has been investigated for its potential role in tissue repair. In rabbit models of collagenase-induced osteoarthritis, intra-articular injections of the peptide were observed to enhance the regeneration of hyaline cartilage. Studies suggest that [AOD-9604] may work synergistically with hyaluronic acid (HA) to improve the structural integrity of joint tissue. The mechanism is hypothesized to involve the stimulation of chondrocytes (cartilage cells) to produce collagen and proteoglycans, essential components of the extracellular matrix.

[AOD-9604] and Inflammation

Emerging research suggests that [AOD-9604] may possess anti-inflammatory properties distinct from its metabolic effects. In vitro studies using human chondrocytes have shown that the peptide may downregulate specific inflammatory markers. This observation aligns with the peptide's origin, as portions of the C-terminal of hGH are known to influence cytokine activity. Researchers are currently exploring whether this pathway contributes to the peptide's efficacy in models of osteoarthritis and tissue injury.

[AOD-9604] and Safety Profile in Research

Extensive toxicology studies in rats and cynomolgus monkeys have characterized the safety profile of [AOD-9604]. Unlike traditional growth hormone treatments, the peptide was not found to induce anti-hGH antibodies or alter IGF-1 serum levels in long-term animal studies. This lack of IGF-1 stimulation is a critical differentiation in research, suggesting that the peptide targets metabolic pathways without activating the proliferative growth pathways associated with oncogenic risk.

If you're not 100% satisfied within the first 30 days, just send it back to us and we'll give you a full refund.

No need to worry about the return shipping - we've got you covered!

We offer fast and reliable shipping on all orders. You can expect to receive it within 7-12 business days based on your location.

Please contact our customer service team for assistance if you have any questions or concerns about your shipment.

While [AOD-9604] has demonstrated a favorable safety profile in animal toxicology studies, potential side effects observed in research settings include mild injection site reactions (redness or irritation). No significant withdrawal effects have been documented in rodent models upon cessation of administration.

ALL PRODUCTS ARE FOR RESEARCH USE ONLY. This product is intended exclusively for laboratory research and development purposes. It is not for human consumption, veterinary use, or therapeutic application. The statements made regarding this product have not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.