{"product_id":"tesamorelin","title":"TESAMORELIN","description":"\u003cp data-path-to-node=\"12\"\u003e\u003cspan class=\"citation-10 citation-end-10\"\u003eTesamorelin is a synthetic analogue of the human Growth Hormone-Releasing Hormone (GHRH).\u003csup class=\"superscript\" data-turn-source-index=\"1\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-9\"\u003eStructurally, it consists of the 44-amino acid sequence of human GHRH, modified at the N-terminus with a\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003ci data-path-to-node=\"12\" data-index-in-node=\"195\"\u003e\u003cspan class=\"citation-9\"\u003etrans-3-hexenoic acid\u003c\/span\u003e\u003c\/i\u003e\u003cspan class=\"citation-9 citation-end-9\"\u003e\u003cspan\u003e \u003c\/span\u003egroup.\u003csup class=\"superscript\" data-turn-source-index=\"2\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eThis modification is critical for the peptide's pharmacodynamic profile, as it significantly increases stability and resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4) compared to endogenous GHRH.\u003c\/p\u003e\n\u003cp data-path-to-node=\"13\"\u003eUpon introduction to the system, Tesamorelin functions as an agonist at the GHRH receptors located on the somatotrophs of the anterior pituitary gland.\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-8 citation-end-8\"\u003eThis binding initiates a signaling cascade that stimulates the synthesis and pulsatile secretion of endogenous growth hormone (GH).\u003csup class=\"superscript\" data-turn-source-index=\"3\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-7 citation-end-7\"\u003e\u003cspan\u003eUnlike direct growth hormone administration, Tesamorelin maintains the natural negative feedback loop involving Insulin-like Growth Factor 1 (IGF-1), which modulates the secretion ceiling and reduces the likelihood of supra-physiological saturation seen in other models.\u003c\/span\u003e\u003csup class=\"superscript\" data-turn-source-index=\"4\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"5 MG","offer_id":47909784813816,"sku":"TESA-10MG-LYO-1","price":38.9,"currency_code":"USD","in_stock":false},{"title":"10 MG","offer_id":47909784846584,"sku":"TESA-10MG-LYO-2","price":69.7,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/TESAMORELIN5MG.jpg?v=1768812414","url":"https:\/\/www.libertylabusa.com\/products\/tesamorelin","provider":"Liberty Labs USA","version":"1.0","type":"link"}