{"product_id":"survodutide","title":"SURVODUTIDE","description":"\u003cp data-path-to-node=\"12\"\u003e\u003cb data-path-to-node=\"12\" data-index-in-node=\"0\"\u003e\u003cspan class=\"citation-22\"\u003eSurvodutide\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-22 citation-end-22\"\u003e\u003cspan\u003e \u003c\/span\u003eis a synthetic peptide analogue designed to function as a dual agonist for both the glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R).\u003csup class=\"superscript\" data-turn-source-index=\"5\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-21 citation-end-21\"\u003eStructurally, it is derived from the glucagon sequence with specific amino acid substitutions to introduce GLP-1 receptor activity and improve proteolytic stability.\u003csup class=\"superscript\" data-turn-source-index=\"6\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-20 citation-end-20\"\u003eA C18 fatty acid side chain is attached to the peptide backbone, which facilitates binding to albumin, thereby extending its half-life and allowing for prolonged biological activity in research settings.\u003csup class=\"superscript\" data-turn-source-index=\"7\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan class=\"citation-20 citation-end-20\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"13\"\u003e\u003cspan class=\"citation-19 citation-end-19\"\u003eThe primary mechanism of action involves the simultaneous activation of two distinct metabolic pathways.\u003csup class=\"superscript\" data-turn-source-index=\"8\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-18\"\u003eActivation of the\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"13\" data-index-in-node=\"123\"\u003e\u003cspan class=\"citation-18\"\u003eGLP-1 receptor\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-18 citation-end-18\"\u003e\u003cspan\u003e \u003c\/span\u003eis associated with the regulation of satiety, delay of gastric emptying, and glucose-dependent insulin secretion.\u003csup class=\"superscript\" data-turn-source-index=\"9\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-17\"\u003eConcurrently, activation of the\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"13\" data-index-in-node=\"284\"\u003e\u003cspan class=\"citation-17\"\u003eglucagon receptor\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-17 citation-end-17\"\u003e\u003cspan\u003e \u003c\/span\u003eis hypothesized to increase energy expenditure and mobilize lipids from the liver.\u003csup class=\"superscript\" data-turn-source-index=\"10\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-16 citation-end-16\"\u003eThis balanced \"twincretin\" activity aims to leverage the synergistic effects of appetite suppression and increased metabolic rate.\u003csup class=\"superscript\" data-turn-source-index=\"11\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"Default Title","offer_id":47862069330168,"sku":"SKU: SURVO-05-LYO","price":358.6,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/SURVODUTIDE10MG.jpg?v=1768669418","url":"https:\/\/www.libertylabusa.com\/products\/survodutide","provider":"Liberty Labs USA","version":"1.0","type":"link"}