{"product_id":"ss-31","title":"SS-31","description":"\u003cp data-path-to-node=\"16\"\u003e\u003cspan class=\"citation-21 citation-end-21\"\u003e[SS-31], also known as Elamipretide, is a synthetic, aromatic-cationic tetrapeptide designed to target the inner mitochondrial membrane (IMM).\u003csup class=\"superscript\" data-turn-source-index=\"7\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eUnlike general antioxidants that scavenge reactive oxygen species (ROS) indiscriminately throughout the cell, [SS-31] possesses a unique structural motif that allows it to penetrate the cell membrane and accumulate selectively within the mitochondria.\u003c\/p\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cspan class=\"citation-20\"\u003eThe primary mechanism of action involves the specific binding of [SS-31] to\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"17\" data-index-in-node=\"76\"\u003e\u003cspan class=\"citation-20\"\u003ecardiolipin\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-20 citation-end-20\"\u003e, a phospholipid exclusively expressed on the inner mitochondrial membrane.\u003csup class=\"superscript\" data-turn-source-index=\"8\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-19 citation-end-19\"\u003eCardiolipin is essential for the structural organization of the electron transport chain (ETC) into supercomplexes, which are required for efficient oxidative phosphorylation.\u003csup class=\"superscript\" data-turn-source-index=\"9\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-18 citation-end-18\"\u003eBy interacting electrostatically and hydrophobically with cardiolipin, [SS-31] is observed to stabilize mitochondrial cristae structure and optimize electron transfer.\u003csup class=\"superscript\" data-turn-source-index=\"10\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eThis interaction is hypothesized to minimize electron leakage, thereby reducing the generation of mitochondrial ROS at the source while maintaining adenosine triphosphate (ATP) production.\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"10 MG","offer_id":47934680957176,"sku":"PEP-SS31-10MG-1","price":59.4,"currency_code":"USD","in_stock":false},{"title":"50MG","offer_id":47934680989944,"sku":"PEP-SS31-10MG-2","price":215.2,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/SS-3110MG.jpg?v=1768816098","url":"https:\/\/www.libertylabusa.com\/products\/ss-31","provider":"Liberty Labs USA","version":"1.0","type":"link"}