{"product_id":"mots-c","title":"MOTS-C","description":"\u003cp data-path-to-node=\"14\"\u003e\u003cspan class=\"citation-27 citation-end-27\"\u003e[MOTS-c] is a peptide of 16 amino acids encoded within the mitochondrial genome, specifically the 12S rRNA region.\u003csup class=\"superscript\" data-turn-source-index=\"7\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-26 citation-end-26\"\u003eUnlike most peptides which are encoded by nuclear DNA, [MOTS-c] is unique as a mitochondrial-derived peptide (MDP).\u003csup class=\"superscript\" data-turn-source-index=\"8\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-25 citation-end-25\"\u003eIt acts as a cellular signal that coordinates mitochondrial function with nuclear gene expression in response to metabolic stress.\u003csup class=\"superscript\" data-turn-source-index=\"9\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cspan class=\"citation-24 citation-end-24\"\u003eThe primary mechanism of action involves the translocation of [MOTS-c] from the mitochondria to the nucleus.\u003csup class=\"superscript\" data-turn-source-index=\"10\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-23 citation-end-23\"\u003eOnce in the nucleus, it interacts with the adaptive nuclear genome to regulate metabolism.\u003csup class=\"superscript\" data-turn-source-index=\"11\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-22 citation-end-22\"\u003eResearch indicates that [MOTS-c] inhibits the folate cycle, which results in an accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).\u003csup class=\"superscript\" data-turn-source-index=\"12\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-21 citation-end-21\"\u003eThis accumulation subsequently activates Adenosine Monophosphate-Activated Protein Kinase (AMPK), a master regulator of cellular energy homeostasis.\u003csup class=\"superscript\" data-turn-source-index=\"13\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-20 citation-end-20\"\u003e\u003cspan\u003eThrough AMPK activation, [MOTS-c] modulates glucose uptake and fatty acid oxidation, functioning similarly to an exercise-mimetic agent.\u003c\/span\u003e\u003csup class=\"superscript\" data-turn-source-index=\"14\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"10 MG","offer_id":47909784682744,"sku":null,"price":49.2,"currency_code":"USD","in_stock":true},{"title":"40 MG","offer_id":47909784715512,"sku":null,"price":159.8,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/mots-c_10_mg.jpg?v=1769616487","url":"https:\/\/www.libertylabusa.com\/products\/mots-c","provider":"Liberty Labs USA","version":"1.0","type":"link"}