{"product_id":"melanotan-i","title":"MELANOTAN I","description":"\u003ch1 data-path-to-node=\"13\"\u003e\u003cb data-path-to-node=\"13\" data-index-in-node=\"0\"\u003eOverview \u0026amp; Mechanism\u003c\/b\u003e\u003c\/h1\u003e\n\u003cp data-path-to-node=\"14\"\u003e\u003cspan class=\"citation-12\"\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003e\u003cspan class=\"citation-12\"\u003e[MELANOTAN I]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-12 citation-end-12\"\u003e (Afamelanotide) is a synthetic tridecapeptide analogue of the endogenous hormone alpha-\u003c\/span\u003e\u003cspan class=\"citation-11 citation-end-11\"\u003eMelanocyte Stimulating Hormone (\u003cem\u003e\u003cspan style=\"font-size: 11.6667px;\"\u003ea\u003c\/span\u003e\u003c\/em\u003e\u003c\/span\u003e\u003cspan class=\"citation-10 citation-end-10\"\u003e-MSH).\u003c\/span\u003e \u003cspan class=\"citation-9 citation-end-9\"\u003eStructurally, it is derived from the replacement of Met at position 4 with Nle (Norleucine) and Phe at position 7 with D-Phe in the native \u003cem\u003e\u003cspan style=\"font-size: 11.6667px;\"\u003ea\u003c\/span\u003e\u003c\/em\u003e\u003c\/span\u003e\u003cspan class=\"citation-8 citation-end-8\"\u003e-MSH sequence.\u003c\/span\u003e These modifications were engineered to significantly increase the peptide's resistance to enzymatic degradation and enhance its binding affinity for melanocortin receptors.\u003c\/p\u003e\n\u003cp\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cspan class=\"citation-7\"\u003eThe primary mechanism of action involves the non-selective agonism of melanocortin receptors, specifically the \u003c\/span\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"111\"\u003e\u003cspan class=\"citation-7\"\u003eMelanocortin 1 Receptor (MC1R)\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-7 citation-end-7\"\u003e located on the surface of melanocytes.\u003c\/span\u003e\u003cspan class=\"citation-6\"\u003eUpon binding to MC1R, \u003c\/span\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"203\"\u003e\u003cspan class=\"citation-6\"\u003e[MELANOTAN I]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-6 citation-end-6\"\u003e activates the adenylate cyclase pathway, leading to an intracellular increase in cyclic adenosine monophosphate (cAMP).\u003c\/span\u003e This signaling cascade upregulates the expression of Microphthalmia-associated Transcription Factor (MITF), subsequently increasing the synthesis of tyrosinase and downstream melanogenic enzymes. The result is the potent stimulation of eumelanin production (photoprotective pigment) independent of ultraviolet (UV) radiation exposure.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"Default Title","offer_id":47862075949304,"sku":"SKU: MT1-10MG-LYO","price":32.8,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/MELANOTANI10MG_2b438314-45b2-40b8-905e-cf1e77ade58d.jpg?v=1769016117","url":"https:\/\/www.libertylabusa.com\/products\/melanotan-i","provider":"Liberty Labs USA","version":"1.0","type":"link"}