{"product_id":"mazdutide","title":"MAZDUTIDE","description":"\u003cp data-path-to-node=\"15\"\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003e\u003cspan class=\"citation-12\"\u003eMAZDUTIDE]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-12 citation-end-12\"\u003e\u003cspan\u003e \u003c\/span\u003eis a synthetic peptide analogue of mammalian oxyntomodulin (OXM), engineered to function as a long-acting dual agonist.\u003csup class=\"superscript\" data-turn-source-index=\"4\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-11\"\u003eIt selectively binds to and activates both the\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"179\"\u003e\u003cspan class=\"citation-11\"\u003eGlucagon-Like Peptide-1 Receptor (GLP-1R)\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-11\"\u003e\u003cspan\u003e \u003c\/span\u003eand the\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"229\"\u003e\u003cspan class=\"citation-11\"\u003eGlucagon Receptor (GCGR)\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-11 citation-end-11\"\u003e.\u003csup class=\"superscript\" data-turn-source-index=\"5\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eStructurally,\u003cspan\u003e \u003c\/span\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"14\"\u003e[MAZDUTIDE]\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003eincorporates a fatty acid side chain attached to the peptide backbone, which facilitates reversible binding to plasma albumin. This modification significantly extends its half-life in vivo compared to native oxyntomodulin, allowing for prolonged receptor engagement.\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-10 citation-end-10\"\u003e\u003cspan\u003eThe primary mechanism involves the synergistic activation of GLP-1R, which enhances glucose-dependent insulin secretion and suppresses appetite, alongside GCGR activation, which is hypothesized to increase energy expenditure and mobilize hepatic lipid stores.\u003c\/span\u003e\u003csup class=\"superscript\" data-turn-source-index=\"6\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"Default Title","offer_id":47889529635064,"sku":"MAZ-05MG-LYO","price":87.1,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/mazdutide10mg_7ee90143-02fa-4572-adb5-7dd54e5a8608.jpg?v=1769616608","url":"https:\/\/www.libertylabusa.com\/products\/mazdutide","provider":"Liberty Labs USA","version":"1.0","type":"link"}