{"product_id":"kpv","title":"KPV","description":"\u003cp data-path-to-node=\"12\"\u003e\u003cb data-index-in-node=\"0\" data-path-to-node=\"12\"\u003e\u003cspan class=\"citation-24\"\u003e[KPV]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-24 citation-end-24\"\u003e is a naturally occurring tripeptide fragment derived from the C-terminal region of \u003cspan class=\"citation-23 citation-end-23\"\u003e\u003cem\u003ea\u003c\/em\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"citation-23 citation-end-23\"\u003e-melanocyte-stimulating hormone (\u003cem\u003ea\u003c\/em\u003e\u003c\/span\u003e\u003cspan class=\"citation-22 citation-end-22\"\u003e-MSH).\u003c\/span\u003e \u003cspan class=\"citation-21\"\u003eUnlike the full-length hormone, \u003c\/span\u003e\u003cb data-index-in-node=\"173\" data-path-to-node=\"12\"\u003e\u003cspan class=\"citation-21\"\u003e[KPV]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-21 citation-end-21\"\u003e does not bind to melanocortin-1 receptors (MC1R) in a manner that induces pigmentation, yet it retains potent anti-inflammatory and immunomodulating properties.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"13\"\u003e\u003cspan class=\"citation-20\"\u003eThe primary mechanism of action involves the inhibition of the \u003c\/span\u003e\u003cb data-index-in-node=\"63\" data-path-to-node=\"13\"\u003e\u003cspan class=\"citation-20 citation-end-20\"\u003eNF-\u003ci\u003ek\u003c\/i\u003e\u003c\/span\u003e\u003cspan class=\"citation-19\"\u003eB\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-19 citation-end-19\"\u003e signaling pathway.\u003c\/span\u003e \u003cspan class=\"citation-18\"\u003eStudies indicate that \u003c\/span\u003e\u003cb data-index-in-node=\"115\" data-path-to-node=\"13\"\u003e\u003cspan class=\"citation-18\"\u003e[KPV]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-18\"\u003e enters cells primarily through the peptide transporter \u003c\/span\u003e\u003cb data-index-in-node=\"176\" data-path-to-node=\"13\"\u003e\u003cspan class=\"citation-18\"\u003ePepT1\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-18 citation-end-18\"\u003e (SLC15A1). Once intracellular, it has been observed to prevent the nuclear translocation of the NF-\u003cb data-index-in-node=\"63\" data-path-to-node=\"13\"\u003e\u003cspan class=\"citation-20 citation-end-20\"\u003e\u003ci\u003ek\u003c\/i\u003eB\u003c\/span\u003e\u003c\/b\u003e\u003c\/span\u003e\u003cspan class=\"citation-17 citation-end-17\"\u003e p65 subunit, thereby reducing the transcription of pro-inflammatory cytokines such as TNF-\u003cspan class=\"citation-23 citation-end-23\"\u003e\u003cem\u003ea\u003c\/em\u003e\u003c\/span\u003e\u003c\/span\u003e\u003cspan class=\"citation-16 citation-end-16\"\u003e, IL-6, and IL-1β.\u003c\/span\u003e \u003cspan class=\"citation-15 citation-end-15\"\u003eThis mechanism allows the peptide to exert effects directly within immune and epithelial cells.\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"Default Title","offer_id":47889672274168,"sku":"PEP-KPV-10MG","price":46.1,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/KPV10MG_c15e92d1-b98f-4041-8ae7-7e60f6c7482d.jpg?v=1769016451","url":"https:\/\/www.libertylabusa.com\/products\/kpv","provider":"Liberty Labs USA","version":"1.0","type":"link"}