{"product_id":"igf-1-lr3","title":"IGF-1 LR3","description":"\u003ch3 data-path-to-node=\"14\"\u003e\u003cb data-path-to-node=\"14\" data-index-in-node=\"0\"\u003eOverview \u0026amp; Mechanism\u003c\/b\u003e\u003c\/h3\u003e\n\u003cp data-path-to-node=\"15\"\u003e\u003cspan class=\"citation-13\"\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"15\" data-index-in-node=\"0\"\u003e\u003cspan class=\"citation-13\"\u003e[IGF-1 LR3]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-13 citation-end-13\"\u003e\u003cspan\u003e \u003c\/span\u003e(Long Arginine 3-IGF-1) is a synthetic, recombinant analog of human Insulin-like Growth Factor-1 (IGF-1).\u003csup class=\"superscript\" data-turn-source-index=\"8\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-12 citation-end-12\"\u003eStructurally, it differs from endogenous IGF-1 by the substitution of Glutamic Acid (Glu) with Arginine (Arg) at position 3, and the addition of a 13-amino acid extension peptide at the N-terminus.\u003csup class=\"superscript\" data-turn-source-index=\"9\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eThe primary mechanism of action for\u003cspan\u003e \u003c\/span\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"36\"\u003e[IGF-1 LR3]\u003c\/b\u003e\u003cspan\u003e \u003c\/span\u003einvolves its high-affinity binding to the Type 1 IGF receptor (IGF-1R). In physiological conditions, native IGF-1 is tightly bound to Insulin-like Growth Factor Binding Proteins (IGFBPs), which inhibit its biological activity and limit its bioavailability.\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-11\"\u003eThe structural modifications in\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"337\"\u003e\u003cspan class=\"citation-11\"\u003e[IGF-1 LR3]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-11 citation-end-11\"\u003e\u003cspan\u003e \u003c\/span\u003edrastically reduce its affinity for these binding proteins.\u003csup class=\"superscript\" data-turn-source-index=\"10\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-10\"\u003eConsequently,\u003cspan\u003e \u003c\/span\u003e\u003c\/span\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"423\"\u003e\u003cspan class=\"citation-10\"\u003e[IGF-1 LR3]\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-10 citation-end-10\"\u003e\u003cspan\u003e exhibits a significantly extended half-life (approximately 20-30 hours compared to 15-20 minutes for native IGF-1) and increased potency in stimulating cellular responses via the PI3K\/Akt and MAPK signaling pathways.\u003c\/span\u003e\u003csup class=\"superscript\" data-turn-source-index=\"11\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"100 MCG","offer_id":47934704484600,"sku":"PEP-IGF1LR3-01","price":29.7,"currency_code":"USD","in_stock":true},{"title":"1000 MCG","offer_id":47934704517368,"sku":"PEP-IGF1LR3-02","price":148.6,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/IGF-1_LR3_100MCG.jpg?v=1768645031","url":"https:\/\/www.libertylabusa.com\/products\/igf-1-lr3","provider":"Liberty Labs USA","version":"1.0","type":"link"}