{"product_id":"cjc-1295","title":"CJC-1295","description":"\u003cp data-path-to-node=\"15\"\u003e\u003cspan class=\"citation-8 citation-end-8\"\u003eCJC-1295 is a synthetic analogue of the endogenous Growth Hormone-Releasing Hormone (GHRH).\u003csup class=\"superscript\" data-turn-source-index=\"3\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eIt is chemically categorized as a tetrasubstituted peptide, specifically modified at the N-terminus to resist enzymatic degradation by Dipeptidyl Peptidase-4 (DPP-IV). This modification significantly extends its biological half-life compared to native GHRH (1-29).\u003c\/p\u003e\n\u003cp data-path-to-node=\"16\"\u003eThe primary mechanism of action involves the binding of CJC-1295 to the GHRH receptors located on the somatotrophs of the anterior pituitary gland.\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-7 citation-end-7\"\u003eUpon binding, it initiates a signal transduction pathway involving the cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA) systems.\u003csup class=\"superscript\" data-turn-source-index=\"4\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eThis signaling cascade stimulates the transcription of the Growth Hormone (GH) gene and the subsequent release of GH into the bloodstream.\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-6 citation-end-6\"\u003eUnlike Growth Hormone Secretagogues (GHSs) which act on the ghrelin receptor, CJC-1295 maintains the physiological pulsatile secretion pattern of growth hormone, preserving the negative feedback loops governed by somatostatin.\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"2 MG","offer_id":47934700290296,"sku":"PEP-CJC-2MG-1","price":28.7,"currency_code":"USD","in_stock":false},{"title":"5 MG","offer_id":47934700323064,"sku":"PEP-CJC-2MG-2","price":46.1,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/CJC-12952MG.jpg?v=1768824641","url":"https:\/\/www.libertylabusa.com\/products\/cjc-1295","provider":"Liberty Labs USA","version":"1.0","type":"link"}