{"product_id":"cjc-1295-ipamorelin","title":"CJC-1295 + IPAMORELIN","description":"\u003cp data-path-to-node=\"20\"\u003e\u003cspan class=\"citation-11 citation-end-11\"\u003eThe [CJC-1295 + IPAMORELIN 5MG + 5MG] blend represents a combination of two distinct classes of Growth Hormone Secretagogues (GHS).\u003csup class=\"superscript\" data-turn-source-index=\"4\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-10 citation-end-10\"\u003eCJC-1295 is a synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) with tetrasubstituted modifications (D-Ala, Gln, Ala, Leu) that protect the peptide from degradation by the enzyme DPP-IV, thereby extending its half-life relative to native GHRH.\u003csup class=\"superscript\" data-turn-source-index=\"5\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-9 citation-end-9\"\u003eIpamorelin is a selective, pentapeptide agonist of the ghrelin receptor (GHS-R1a), originating from a series of compounds lacking the central dipeptide Ala-Trp of older GHRPs, designed to minimize off-target signaling.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"21\"\u003eThe primary mechanism of action involves a synergistic activation of the pituitary somatotrophs. CJC-1295 binds to the GHRH receptor to increase cAMP levels, priming the cell for hormone release, while Ipamorelin binds to the GHS-R1a receptor to amplify the depolarization and secretory signal.\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-8 citation-end-8\"\u003e\u003cspan\u003eThis dual-pathway stimulation is observed in research to produce a robust, physiological pulse of Growth Hormone (GH) without the significant elevation of cortisol or prolactin often seen with non-selective secretagogues like GHRP-2 or GHRP-6.\u003c\/span\u003e\u003csup class=\"superscript\" data-turn-source-index=\"7\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"Default Title","offer_id":47893044527352,"sku":"CJCIPA-55-LYO","price":69.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/CJC-1295_IPAMORELIN5MG_5MG.jpg?v=1768810033","url":"https:\/\/www.libertylabusa.com\/products\/cjc-1295-ipamorelin","provider":"Liberty Labs USA","version":"1.0","type":"link"}