{"product_id":"cagrilintide","title":"CAGRILINTIDE","description":"\u003cp data-path-to-node=\"16\"\u003e\u003cspan class=\"citation-21 citation-end-21\"\u003eCagrilintide is a synthetic, long-acting analogue of the pancreatic hormone amylin (islet amyloid polypeptide).\u003csup class=\"superscript\" data-turn-source-index=\"4\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-20 citation-end-20\"\u003eStructurally, it is an acylated peptide designed to overcome the instability and rapid clearance associated with native amylin.\u003csup class=\"superscript\" data-turn-source-index=\"5\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-19 citation-end-19\"\u003eThe peptide acts as a non-selective agonist for both the amylin receptors (AMY) and the calcitonin G protein-coupled receptor (CTR), classifying it as a Dual Amylin and Calcitonin Receptor Agonist (DACRA).\u003csup class=\"superscript\" data-turn-source-index=\"6\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"17\"\u003e\u003cspan class=\"citation-18 citation-end-18\"\u003eThe primary mechanism of action involves the activation of amylin receptors located in the hindbrain, specifically the area postrema and the nucleus of the solitary tract.\u003csup class=\"superscript\" data-turn-source-index=\"7\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-17 citation-end-17\"\u003eUpon binding, Cagrilintide is observed to modulate homeostatic and hedonic signaling pathways involved in satiety.\u003csup class=\"superscript\" data-turn-source-index=\"8\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003cspan class=\"citation-16 citation-end-16\"\u003eUnlike selective GLP-1 agonists, Cagrilintide’s affinity for the calcitonin receptor provides a distinct, complementary pathway for metabolic regulation.\u003csup class=\"superscript\" data-turn-source-index=\"9\"\u003e\u003c\/sup\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003eIn research settings, the peptide demonstrates the ability to cross the blood-brain barrier to engage central nervous system targets responsible for energy balance and gastric motility.\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"5 MG","offer_id":47934699110648,"sku":"CAG-005-LYO-1","price":56.4,"currency_code":"USD","in_stock":false},{"title":"10 MG","offer_id":47934699143416,"sku":"CAG-005-LYO-2","price":100.4,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/CAGRILINTIDE5MG.jpg?v=1768824308","url":"https:\/\/www.libertylabusa.com\/products\/cagrilintide","provider":"Liberty Labs USA","version":"1.0","type":"link"}