{"product_id":"5-amino-1mq","title":"5-AMINO-1MQ","description":"\u003cp data-path-to-node=\"16\"\u003e\u003cb data-path-to-node=\"16\" data-index-in-node=\"0\"\u003e\u003cspan class=\"citation-18\"\u003e5-Amino-1MQ\u003c\/span\u003e\u003c\/b\u003e\u003cspan class=\"citation-18 citation-end-18\"\u003e is a small-molecule, membrane-permeable compound chemically synthesized to function as a selective inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT).\u003c\/span\u003e \u003cspan class=\"citation-17 citation-end-17\"\u003eUnlike traditional peptides which are chains of amino acids, 5-Amino-1MQ is a quinolinium derivative designed to target cytosolic enzymatic pathways.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c!----\u003e\u003c\/p\u003e\n\u003cp data-path-to-node=\"17\"\u003eThe primary mechanism of action involves the competitive inhibition of NNMT. \u003cspan class=\"citation-16 citation-end-16\"\u003eUnder normal physiological conditions, NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide (NA), producing 1-methylnicotinamide (1-MNA).\u003c\/span\u003e This process effectively removes nicotinamide from the salvage pathway, preventing it from being recycled into Nicotinamide Adenine Dinucleotide (\u003cspan class=\"math-inline\" data-math=\"NAD^+\" data-index-in-node=\"402\"\u003eNAD+\u003c\/span\u003e). \u003cspan class=\"citation-15 citation-end-15\"\u003eBy inhibiting NNMT, 5-Amino-1MQ facilitates the accumulation of nicotinamide and subsequently elevates intracellular \u003c\/span\u003e\u003cspan class=\"math-inline\" data-math=\"NAD^+\" data-index-in-node=\"527\"\u003eNAD+\u003c\/span\u003e\u003cspan class=\"citation-14 citation-end-14\"\u003e concentrations.\u003c\/span\u003e \u003cspan class=\"citation-13 citation-end-13\"\u003eElevated \u003c\/span\u003e\u003cspan class=\"math-inline\" data-math=\"NAD^+\" data-index-in-node=\"558\"\u003eNAD+\u003c\/span\u003e\u003cspan class=\"citation-12 citation-end-12\"\u003e is a critical cofactor for mitochondrial metabolism and is essential for the activation of sirtuins (SIRT1), a family of proteins associated with metabolic regulation and cellular longevity.\u003c\/span\u003e\u003c\/p\u003e","brand":"Liberty Labs USA","offers":[{"title":"Default Title","offer_id":47893962653944,"sku":"5A-1MQ-10","price":76.8,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/0773\/3240\/files\/5-AMINO-1MQ.jpg?v=1768811515","url":"https:\/\/www.libertylabusa.com\/products\/5-amino-1mq","provider":"Liberty Labs USA","version":"1.0","type":"link"}